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Small molecule inhibitor Antineoplastic Drugs R-406 841290-80-0

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Small molecule inhibitor Antineoplastic Drugs R-406 841290-80-0

China Small molecule inhibitor Antineoplastic Drugs R-406 841290-80-0 supplier
Small molecule inhibitor Antineoplastic Drugs R-406 841290-80-0 supplier Small molecule inhibitor Antineoplastic Drugs R-406 841290-80-0 supplier

Large Image :  Small molecule inhibitor Antineoplastic Drugs R-406 841290-80-0

Product Details:

Place of Origin: Weifang,China
Brand Name: RuzE
Model Number: TC-6017

Payment & Shipping Terms:

Minimum Order Quantity: Negotiable
Price: Negotiable
Delivery Time: 5-10work days
Payment Terms: L/C, T/T, Western Union, MoneyGram
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Detailed Product Description
Product Name: R-406 CAS: 841290-80-0
MF: C22H23FN6O5 MW: 470.459
EINECS: 617-533-5 Mol File: 841290-80-0.mol

 

Small molecule inhibitor Antineoplastic Drugs R-406 841290-80-0

R-406(841290-80-0)

 

[PRODUCTNAME]:6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one

[CATALOG NUMBER]:

[CAS NUMBER]:841290-80-0

[MOLECULAR FORMULA]:C22H23FN6O5

[MOLECULAR WEIGHT]:470.45400

[BATCH NO]: 20190218

[TEST]:SPECIFICATION

[APPEARANCE]: White Solid

[ASSAY]: 98%min

[WATER]: 0.5%max


R-406 Usage And Synthesis


Uses Intermediate used for preparation of prodrugs of pyrimidine-2,4-diamines as anticancer agents.
Uses R406 is a potent ATP-competitive inhibitor of spleen tyrosine kinase (Syk, Ki = 30 nM). Through this action, R406 blocks FcεRI-dependent mast cell activation (EC50 = 43 nM) and, at 3 μM, reduces the release of IL-10, -12, and -13 by immune complex-pulsed dendritic cells. R406 is orally available and can reduce immune complex-mediated inflammation. In cancers characterized by over-expression of Syk, R406 can prevent signaling downstream of Syk and induce apoptosis. R406 also inhibits Syk-dependent signaling through c-Jun N-terminal kinase in rheumatoid arthritis synoviocytes, suggesting a therapeutic intervention in this autoimmune disease.[Cayman Chemical]

 

 

 

Small molecule inhibitor Antineoplastic Drugs R-406 841290-80-0Small molecule inhibitor Antineoplastic Drugs R-406 841290-80-0

Small molecule inhibitor Antineoplastic Drugs R-406 841290-80-0Small molecule inhibitor Antineoplastic Drugs R-406 841290-80-0Small molecule inhibitor Antineoplastic Drugs R-406 841290-80-0

 

Small molecule inhibitor Antineoplastic Drugs R-406 841290-80-0

 

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