Product: Linagliptin CAS: 668270-12-0 Molecular Formula:C25H28N8O2 Purity :99.0% Specification:Enterprise Standard
Appearance:white crystal powder
What's the Linagliptin?
Linagliptin is a DPP-4 inhibitor developed by Boehringer Ingelheim for treatment of type II diabetes. Linagliptin was approved by the U.S. Food and Drug Administration (FDA) on 2 May 2011 for treatment of type II diabetes.
White or off white crystalline powder
The sample spectrum corresponds to that of the
The retention time of the major peak in the
chromatogram of the sample corresponds to that exhibited by the working standard
Loss on drying
No more than 1.0%
Residue on ignition
No more than 0.1%
No more than 20ppm
Total impurities no more than 1.5%
Single impurity no more than 0.5%
Ethyl acetate No more than 0.2%
Ethanol No more than 0.2%
No less than 98.5%
Conforms to the In-house standard.
1. Incretin (Incretin) has the role of intestinal promoting insulin B cells to secrete insulin, mainly including glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1). DDP-4 is a serine protease located on the cell surface, which is widely found in plasma and in vivo tissues (such as kidney, liver, small intestine villi, endothelial cells, etc.). Rilalitine is a selective DPP-4 inhibitor that inhibits the activity of the enzyme by reversibly binding to DPP-4, delays GLP-1 degradation, enhances GLP-1 activity, and stimulates glucose-dependent Insulin secretion, and reduce circulating levels of glucagon, thereby regulating blood glucose levels in patients with type 2 diabetes.
2. Compared with other DPP-4 inhibitors, the main advantages of liradetine is: with excellent renal safety, and can effectively reduce glycosylated hemoglobin. Lilardine mainly in the form of excretion of fecal excretion, the oral administration, the amount of renal excretion is only 5% of the dose, even if the intravenous administration, and only 30.8% of the excretion by the kidney, so the patient did not need treatment Regularly check the liver, kidney function and dose adjustment, all patients can be a unified fixed dose, easy to prescribe.
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or upon customers' request.
Store in a well-closed container away from moisture
2 years if sealed and store away from direct sun light.