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Customer Synthesis Pulmonary arterial hypertension Medicine 441798-33-0 Assay99%

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Customer Synthesis Pulmonary arterial hypertension Medicine 441798-33-0 Assay99%

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Product Details:

Place of Origin: Weifang,China
Brand Name: RuzE
Model Number: TC-5041

Payment & Shipping Terms:

Minimum Order Quantity: Negotiable
Price: Negotiable
Packaging Details: 1kg Falumium Foil bag or As customer request
Delivery Time: 5-10work days
Payment Terms: L/C, T/T, Western Union, MoneyGram
Supply Ability: 20kg/Month
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Detailed Product Description
Product Name: Macitentan Synonyms: Macitentan (Actelion-1,ACT-064992);N-[5-(4-Bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)-oxy]ethoxy]-4-pyrimidinyl]-N'-propylsulfami;macitentan;N-[5-(4-Bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-N'-propylsulfamide;ACT 064992;ACT-0649
CAS: 441798-33-0 MF: C19H22Br2N6O4S
MW: 590.295 EINECS: 1308068-626-2

Weifang Ruze New Material Co.,LTD a China supplier of macitentan (CAS No.: 441798-33-0),CAS 441798-33-0 offers for your requirements of RND, evaluation, pilots and commercial along with supportive technical package required for evaluation.


Customer Synthesis Pulmonary arterial hypertension Medicine  441798-33-0 Assay99%

                                                                                                                                                                           

                                                                           macitentan

 

[PRODUCT NAME]:macitentan

[CATALOG NUMBER]:ZHY-0009

[CAS NUMBER]:441798-33-0

[MOLECULAR FORMULA]:C19H22Br2N6O4S

[MOLECULAR WEIGHT]:590.28900

[BATCH NO]:20190225

[TEST]:SPECIFICATION

[APPEARANCE]:White Powder

[ASSAY]:99%min

[WATER]:0.5%max


macitentan Chemical Properties

density 1.675

 

macitentan Usage And Synthesis

Description Macitentan (also known as ACT-064992) received US FDA approval in October 2013 for the treatment of pulmonary arterial hypertension (PAH) (WHO group I) to delay disease progression. Treatment options include phosphodiesterase type 5 inhibitors, prostacyclins, and the endothelin receptor antagonists bosentan and ambrisentan. Macitentan was discovered through SAR studies starting with the bosentan structure with three main goals: (1) to increase potency for both endothelin receptor A and B (ETA and ETB) subtypes; (2) to improve tissue distribution to reach the target receptors; and (3) to avoid bile salt transport inhibition. Starting with the bosentan sulfonamido-pyrimidinyl central core, potency was increased 10-fold via incorporation of a bromopyrimidinyl ethylene glycol ether, as found in the clinical endothelin antagonist, T-0201. An aryl ether in bosentan was replaced with the bromophenyl group in macitentan, and a substituent on the 2-position of the central pyrimidine was replaced with hydrogen. Several sulfonamides and alkyl sulfamates were explored, with the propylsulfamate providing the best combination of in vitro potency, especially for ETB antagonism, and in vivo efficacy.
Originator Actelion Pharmaceuticals Ltd. (Switzerland)
Definition ChEBI: A member of the class of sulfamides in which the two amino groups of sulfonamide are substituted by 5-(4-bromophenyl)-6-{2-[(5-bromopyrimidin-2-yl)oxy]ethoxy}pyrimidin-4-yl and propyl groups. An orphan drug used for the treatment of pulmonary arterial hype tension.
Brand name Opsumit

Customer Synthesis Pulmonary arterial hypertension Medicine  441798-33-0 Assay99%Customer Synthesis Pulmonary arterial hypertension Medicine  441798-33-0 Assay99%

Customer Synthesis Pulmonary arterial hypertension Medicine  441798-33-0 Assay99%Customer Synthesis Pulmonary arterial hypertension Medicine  441798-33-0 Assay99%Customer Synthesis Pulmonary arterial hypertension Medicine  441798-33-0 Assay99%

 

Customer Synthesis Pulmonary arterial hypertension Medicine  441798-33-0 Assay99%


 

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