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China synthesis lab supply Inhibitors Cabazitaxel CAS: 183133-96-2 Antineoplastic Drugs

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China synthesis lab supply Inhibitors Cabazitaxel CAS: 183133-96-2 Antineoplastic Drugs

China China synthesis lab supply Inhibitors  Cabazitaxel CAS: 183133-96-2 Antineoplastic Drugs supplier
China synthesis lab supply Inhibitors  Cabazitaxel CAS: 183133-96-2 Antineoplastic Drugs supplier China synthesis lab supply Inhibitors  Cabazitaxel CAS: 183133-96-2 Antineoplastic Drugs supplier

Large Image :  China synthesis lab supply Inhibitors Cabazitaxel CAS: 183133-96-2 Antineoplastic Drugs

Product Details:

Place of Origin: Weifang,China
Brand Name: RuzE
Model Number: TC-6000

Payment & Shipping Terms:

Minimum Order Quantity: Negotiable
Price: Negotiable
Packaging Details: 1kg, 5kg Alumium Foil Bag
Delivery Time: 5-10work days
Payment Terms: L/C, T/T, Western Union, MoneyGram
Supply Ability: 25kg/Month
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Detailed Product Description
Product Name: Cabazitaxel Synonyms: β-[[(1,1-DiMethylethoxy)carbonyl]aMino]-α-hydroxybenzenepropanoic Acid [2aR-[2aα,4β,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]-12b-(Acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4,6-diMethoxy-4a,8,13,13-tetraMethyl
CAS: 183133-96-2 MF: C45H57NO14
MW: 835.93238 EINECS: 680-632-7

China synthesis lab supply Inhibitors  Cabazitaxel CAS: 183133-96-2 Antineoplastic Drugs
 
Cabazitaxel
 
[PRODUCT NAME]:Cabazitaxel
[CATALOG NUMBER]:
[CAS NUMBER]:183133-96-2
[MOLECULAR FORMULA]:C45H57NO14
[MOLECULAR WEIGHT]:835.93200
[BATCH NO]: 20190226
[TEST]:SPECIFICATION
[APPEARANCE]: White Powder
[ASSAY]: 99%min
[WATER]: 0.5%max


Cabazitaxel Chemical Properties


density1.31
formWhite solid.

Safety Information


Safety Statements24/25
HS Code29329990

Cabazitaxel Usage And Synthesis


DescriptionIn June 2010, the U.S. FDA approved cabazitaxel (also referred to as XRP6258 and RPR 116258A) in combination with the steroid prednisone for the treatment of metastatic Castration-Resistant Prostate Cancer (mCRPC) for patients who were previously treated with a docetaxelcontaining regimen for late-stage disease.
Cabazitaxel is a semisynthetic analog of the natural product taxol, which is isolated from the bark of the yew tree. Cabazitaxel is a microtubule inhibitor that binds to the taxol-binding site of tubulin. Similar to other tubulin inhibitors of the taxol class, cabazitaxel inhibits microtubule disassembly resulting in mitotic blockade and cell death. Docetaxel, also a semisynthetic taxol analog, was approved by the FDA for the treatment of mCRPC in 2004. However, docetaxel is a substrate for P-gp, which is thought to contribute to the constitutive and acquired resistance of cancer cells to taxanes. Cabazitaxel has poor affinity for P-gp and showed antitumor activity in preclinical in vitro studies and in vivo tumor models that overexpress this protein. Cabazitaxel is synthesized on a commercial scale from 10-deacetylbaccatin .
Chemical PropertiesWhite solid
OriginatorSanofi-Aventis (France)
UsesCabazitaxel (Jevtana, XRP6258) is a semi-synthetic derivative of a natural taxoid.
UsesA novel semi-synthetic taxane with antitumor activity used for the treatment of castration-resistant prostate cancer. A microtubule inhibitor.
DefinitionChEBI: A tetracyclic diterpenoid that is 10-deacetylbaccatin III having O-methyl groups attached at positions 7 and 10 as well as an O-(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hy roxy-3-phenylpropanoyl group attached at position 13. Acts as a microtubule inhibitor, binds tubulin and promotes microtubule assembly and simultaneously inhibits disassembly.
Brand nameJevtana

 
China synthesis lab supply Inhibitors  Cabazitaxel CAS: 183133-96-2 Antineoplastic DrugsChina synthesis lab supply Inhibitors  Cabazitaxel CAS: 183133-96-2 Antineoplastic Drugs
China synthesis lab supply Inhibitors  Cabazitaxel CAS: 183133-96-2 Antineoplastic DrugsChina synthesis lab supply Inhibitors  Cabazitaxel CAS: 183133-96-2 Antineoplastic DrugsChina synthesis lab supply Inhibitors  Cabazitaxel CAS: 183133-96-2 Antineoplastic Drugs

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