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Brigatinib Antineoplastic Drugs Cas 1197953-54-0 White Crystal Powder High Assay

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Brigatinib Antineoplastic Drugs Cas 1197953-54-0 White Crystal Powder High Assay

China Brigatinib Antineoplastic Drugs Cas 1197953-54-0 White Crystal Powder High Assay supplier
Brigatinib Antineoplastic Drugs Cas 1197953-54-0 White Crystal Powder High Assay supplier Brigatinib Antineoplastic Drugs Cas 1197953-54-0 White Crystal Powder High Assay supplier

Large Image :  Brigatinib Antineoplastic Drugs Cas 1197953-54-0 White Crystal Powder High Assay

Product Details:

Place of Origin: Weifang,China
Brand Name: Ruze
Certification: COA MSDS
Model Number: 1197953-54-0

Payment & Shipping Terms:

Minimum Order Quantity: Negotiable
Price: Negotiable
Packaging Details: 1kg/drum
Delivery Time: 5-7 work days
Payment Terms: L/C, T/T, Western Union, MoneyGram
Supply Ability: 1000kg/week
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Detailed Product Description
CAS: 1197953-54-0 MF: C29H39ClN7O2P
MW: 584.092421 EINECS: 1592732-453-0
Boiling Point: 781.8±70.0 °C(Predicted) Density: 1.31±0.1 G/cm3(Predicted)
Acidity Coefficient (pKa): 8.14±0.42(Predicted)

 
 

 

Brigatinib Antineoplastic Drugs Cas 1197953-54-0 White Crystal Powder High Assay

 

 

Product Name: Brigatinib
Synonyms: Brigatinib;AP26113 (Brigatinib);Brigatinib, AP26113;5-Chloro-N4-[2-(dimethylphosphinyl)phenyl]-N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-2,4-pyrimidinediamine;5-chloro-N4-(2-(dimethylphosphoryl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine
CAS: 1197953-54-0
MF: C29H39ClN7O2P
MW: 584.092421
EINECS: 1592732-453-0
Product Categories: API
Mol File: 1197953-54-0.mol

 

What is Brigatinib?

Brigatinib is an orally available inhibitor of receptor tyrosine kinases anaplastic lymphoma kinase (ALK) and the epidermal growth factor receptor (EGFR) with potential antineoplastic activity. Brigatinib binds to and inhibits ALK kinase and ALK fusion proteins as well as EGFR and mutant forms. This leads to the inhibition of ALK kinase and EGFR kinase, disrupts their signaling pathways and eventually inhibits tumor cell growth in susceptible tumor cells. In addition, AP26113 appears to overcome mutation-based resistance. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development; ALK dysregulation and gene rearrangements are associated with a series of tumors. EGFR is overexpressed in a variety of cancer cell types.

 

Application

 

Brigatinib, also known as AP-26113, is an orally active, potent and selective Dual ALK/EGFR inhibitor. AP26113 binds to and inhibits ALK kinase and ALK fusion proteins as well as EGFR and mutant forms. This leads to the inhibition of ALK kinase and EGFR kinase, disrupts their signaling pathways and eventually inhibits tumor cell growth in susceptible tumor cells. In addition, AP26113 appears to overcome mutation-based resistance. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development; ALK dysregulation and gene rearrangements are associated with a series of tumors. EGFR is overexpressed in a variety of cancer cell types.

 

 

 

Brigatinib Antineoplastic Drugs Cas 1197953-54-0 White Crystal Powder High AssayBrigatinib Antineoplastic Drugs Cas 1197953-54-0 White Crystal Powder High Assay

Brigatinib Antineoplastic Drugs Cas 1197953-54-0 White Crystal Powder High AssayBrigatinib Antineoplastic Drugs Cas 1197953-54-0 White Crystal Powder High AssayBrigatinib Antineoplastic Drugs Cas 1197953-54-0 White Crystal Powder High Assay

 

Brigatinib Antineoplastic Drugs Cas 1197953-54-0 White Crystal Powder High Assay

 

We have complete experimental facilities. And advanced testing instruments ensure the stability of product quality from all aspects. We have a complete sales service system, the products are exported to countries all over the world, and have won a good international reputation with excellent quality and excellent service.Our business is based on honesty and mutual trust. Sincerely look forward to establishing long-term mutually beneficial and good cooperation with customers all over the world.

 

 

Packaging Detail

0.5kgs/Al-Bottle

1.0kgs/Al- Bottle

2.0kgs/Al- Bottle

5.0 kgs/Al-Bottle

25.0 kgs/drum

or upon customers' request.

Storage Store in a well-closed container away from moisture
Shelf Life 2 years if sealed and store away from direct sun light.
Delivery Detail within 3 days after get the payment

Contact Details
Weifang Ruze New Material Co., Ltd.

Contact Person: Ma

Tel: 86-13583611556

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