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Bacterial protein synthesis inhibitor Tedizolid Phosphate 856867-55-5

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Bacterial protein synthesis inhibitor Tedizolid Phosphate 856867-55-5

China Bacterial protein synthesis inhibitor Tedizolid Phosphate 856867-55-5 supplier
Bacterial protein synthesis inhibitor Tedizolid Phosphate 856867-55-5 supplier Bacterial protein synthesis inhibitor Tedizolid Phosphate 856867-55-5 supplier

Large Image :  Bacterial protein synthesis inhibitor Tedizolid Phosphate 856867-55-5

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Place of Origin: Weifang,China
Brand Name: RuzE
Model Number: TC-5002

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Minimum Order Quantity: Negotiable
Price: Negotiable
Packaging Details: 100g,1kg, As customer request
Delivery Time: 5-10work days
Payment Terms: L/C, T/T, Western Union, MoneyGram,
Supply Ability: 25kg/Month
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Detailed Product Description
Product Name: Tedizolid Phosphate Synonyms: (R)-(3-(3-fluoro-4-(6-(2-methyl-2H-tetrazol-5-yl)pyridin-3-yl)phenyl)-2-oxooxazolidin-5-yl)methyl Dihydrogen Phosphate;(R) -3- (4- (2- (2- Methyl-tetrazol-5-yl) Pyridin-5-yl) -3-fluorophenyl) -5-hydroxymethyl-oxazolidin-2-one Phosphate;Tedizolid Phosphate
CAS: 856867-55-5 MF: C17H18FN6O7P
MW: 468.3329842 EINECS: 1592732-453-0

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Bacterial protein synthesis inhibitor Tedizolid Phosphate 856867-55-5

             

                                                                  tedizolid phosphate

 

[PRODUCT NAME]: tedizolid phosphate

[CATALOG NUMBER]:

[STRUCTURE]:

[CAS NUMBER]:856867-55-5

[MOLECULAR FORMULA]:C17H16FN6O6P

[MOLECULAR WEIGHT]:450.31800

[BATCH NO]:20190302

[TEST]:SPECIFICATION

[APPEARANCE] :White Solid

[ASSAY]:99%min

[WATER]:0.5%max


 

edizolid Phosphate Usage And Synthesi


A new antibacterial drug Tedizolid phosphate is a new anti-bacterial drug developed by CUBIST PHARMS company. Tedizolid phosphate is a prodrug of Tedizolid. After oral or intravenous administration, Tedizolid phosphate is converted to Tedizolid by phosphatase. Tedizolid is the second generation of oxazolidinone antibiotics, a protein synthesis inhibitors. binding the 50S subunit of bacterial ribosomes, it can inhibit protein synthesis and play a role of antibacterial. It is not easy to have cross-resistance with other types of antibiotics, and has a longer half-life compared to linezolid.
On June 20, 2014, the US Food and Drug Administration (FDA) approved Tedizolid phosphate for use in certain sensitive bacterial-induced adult acute bacterial skin and skin structure infections (ABSSSI), with trade name SIVEXTRO, specification 200 mg. Tedizolid phosphate has been submitted a listing application in Europe and Canada currently, while the drug has not yet listed in China. Tedizolid's listing application is based on clinical trials ESTABLISH 1 and ESTABLISH 2. The results showed that Tedizolid achieved its primary endpoint and secondary endpoint in clinical trials of ABSSSI (defined by the FDA and the European Medicines Agency).
Clinical studies have shown that Tedizolid not only has a better clinical efficacy, and but shortened the treatment cycle by 40% compared with linezolid.
In addition, the study of Tedizolid for hospital acquired/ventilator-associated bacterial pneumonia (HABP/VABP) has entered the clinical phase II.
Analyst Larry Smith predicts the drug will sell more than $ 1 billion by 2020.
This information was edited by Xiao Nan from Chemicalbook (2015-08-14).
Indications Tedizolid (Tedizolid Phosphate, Tidizolamide) is oxazolidinone compounds for serious Gram-positive bacterial infection treatment:
Acute bacterial skin and skin structure infections and complex skin and soft tissue infections (absssi/cSSTI, IV/oral) (to be approved).
Hospital Acquired/Ventilator-Associated Bacterial Pneumonia (HABP/VABP) (Clinical Phase II).
SIVEXTRO is a class of oxazolidinone-based antimicrobials designed for Acute bacterial skin and skin structure infections (ABSSSI). In order to reduce the development of resistant bacteria and to maintain the effectiveness of SIVEXTRO and other antimicrobial agents, SIVEXTRO should only be used to treat or prevent infections that have been proven or strongly suspected to be bacterial-induced.
Definition ChEBI: A phosphate monoester resulting from the formal condensation of equimolar amounts of phosphoric acid with the hydroxy group of tedizolid . It is a prodrug of tedizolid, used for the treatment of acute bacterial skin infections caused by certain susceptibl bacteria, including Staphylococcus aureus (including methicillin-resistant strains (MRSA) and methicillin-susceptible strains), various Streptococcus species, and Enterococcus faecalis.

Bacterial protein synthesis inhibitor Tedizolid Phosphate 856867-55-5Bacterial protein synthesis inhibitor Tedizolid Phosphate 856867-55-5

Bacterial protein synthesis inhibitor Tedizolid Phosphate 856867-55-5Bacterial protein synthesis inhibitor Tedizolid Phosphate 856867-55-5Bacterial protein synthesis inhibitor Tedizolid Phosphate 856867-55-5

 

Bacterial protein synthesis inhibitor Tedizolid Phosphate 856867-55-5


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